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I'm looking for document class downloads for LyX, i.e. .cls and .layout files for multiple purposes, mostly life sciences article writing. Anyone familiar with a source for a collection of those?

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Welcome to TeX.SE! –  ℝaphink Jul 4 '11 at 8:33
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All available layout files are already part of the default LyX installation. For other classes you have to create new or adopt an existing layout file.

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