You can include the pictures using \includegraphics.
In order to ensure to get one cartoon per page, I would call it from the header rendering, using \srcpage2 for example.
Here is an example:
\documentclass[paper=a4]{scrbook}
\usepackage{scrpage2}
\usepackage{graphicx}
\newcommand{\cartoon}[1]{%
\begin{picture}(0,0)
\put(#1,-200){\includegraphics[width=35mm]{xkcd/\thepage.jpg}}
\end{picture}
}
\cehead[\cartoon{-320}]{}
\cohead[\cartoon{220}]{}
\pagestyle{scrplain}
\usepackage{blindtext}
\begin{document}
\Blinddocument
\end{document}
And the result, alternating margins:



Edit: Upon re-reading your question, I just saw you only wanted odd margins. Just remove the \cehead and you'll only have odd margins.