Just to summarize Joseph's NO and add a but. If you are willing to spend a lot longer than simply translating the code you had the misfortune to inherit, here is a methodology.
First you need to write gobbling macros for all the pict2e macros, including also a whole lot of macros from the original picture environment as well. How you do that? For example to gobble the \picture macro you can use:
\def\picture(#1,#2)(#3,#4){%
\def\storepiconevar{#1}
\def\storepictwovar{#2}
\def\storepictthreevar{#3}
\def\storepicfourvar{#4}
% starts the tikZ environment
\tikzpicture
}
% ends the tikZ environment
\def\endpicture{\endtikzpicture}
For some you maybe able to develop translation macros between the two such as the simplistic example below (not showing any actual calculations for simplicity).
\def\line(#1,#2)#3{\draw(#2,#1)--(#1,#1);}
Trying it out in a MWE:
\documentclass{article}
\usepackage{tikz}
\def\picture(#1,#2)(#3,#4){%
\def\storepiconevar{#1}
\def\storepictwovar{#2}
\def\storepictthreevar{#3}
\def\storepicfourvar{#4}
% starts the tikZ environment
\tikzpicture
}
\def\endpicture{\endtikzpicture}
\def\line(#1,#2)#3{\draw(#2,#1)--(#1,#1);}
\begin{document}
\unitlength=0.5cm
\begin{picture}(0,0)(2,0)
\line(1,0){2}
\end{picture}
\end{document}
Worth a try if you want to learn both pict2e and tikZ very well. Let us know if you come up with a package.