In the following example I defined a new command \FramedImage with one optional argument (the options to be used in the optional argument of \includegraphics) and a mandatory one (the name of the image file). This command places its contents inside a minipage enclosed in a \fbox to obatin the frame:
\documentclass{article}
\usepackage[a4paper,margin=2cm,landscape]{geometry}
\usepackage[demo]{graphicx}
\newcommand\FramedImage[2][]{%
\setlength\fboxsep{2pt}% change according to needs
\setlength\fboxrule{3pt}%
\noindent\fbox{%
\begin{minipage}[c][\dimexpr.5\textheight-1.5\fboxrule-2\fboxsep\relax][c]{\dimexpr.5\textwidth-1.5\fboxrule-2\fboxsep\relax}
\centering
\includegraphics[#1]{#2}
\end{minipage}}%
}
\begin{document}
\thispagestyle{empty}
\FramedImage{image1}\hspace*{-3pt}\FramedImage{image2}\\[-3pt]\offinterlineskip
\FramedImage{image3}\hspace*{-3pt}\FramedImage{image4}
\end{document}

The demo option for graphicx simply replaces actual figures with black rectangles; do not use that option in your actual document.