This "crazy" variant of a fraction is generated by \underline and an operator subscript:
\documentclass[12pt,reqno]{amsart}
\usepackage{amsfonts}
\usepackage{amsmath}
\begin{document}
\begin{align}
\label{eq:3of3}
\int_{0}^{1} \phi(p)\mathop{\underline{Q''(p)}}\limits_{\textstyle2}
\int_{0}^{1} (\Delta p)^{2}\mathcal{P}(\Delta p)\; \mathrm{d}p'\; \mathrm{d}p
\end{align}
\end{document}

For comparison, other variants from the comments:
\documentclass[12pt,reqno]{amsart}
\usepackage{amsfonts}
\usepackage{amsmath}
\begin{document}
\begin{align}
\label{eq:3of3}
\int_{0}^{1} \frac{\phi(p)\, Q''(p)}{2}
\int_{0}^{1} (\Delta p)^{2}\mathcal{P}(\Delta p)\; \mathrm{d}p'\; \mathrm{d}p
\end{align}
\end{document}

\documentclass[12pt,reqno]{amsart}
\usepackage{amsfonts}
\usepackage{amsmath}
\begin{document}
\begin{align}
\label{eq:3of3}
\int_{0}^{1} \frac{1}{2}\,\phi(p)\, Q''(p)
\int_{0}^{1} (\Delta p)^{2}\mathcal{P}(\Delta p)\; \mathrm{d}p'\; \mathrm{d}p
\end{align}
\end{document}

With smaller digits:
\documentclass[12pt,reqno]{amsart}
\usepackage{amsfonts}
\usepackage{amsmath}
\usepackage{textcomp}
\begin{document}
\begin{align}
\label{eq:3of3}
\int_{0}^{1} \tfrac{1}{2}\, \phi(p)\, Q''(p)
\int_{0}^{1} (\Delta p)^{2}\mathcal{P}(\Delta p)\; \mathrm{d}p'\; \mathrm{d}p
\end{align}
\end{document}

\phi(p)in the numerator, as well? – Andrew Uzzell Oct 12 '12 at 14:43\frac{1}{2}in front of theQ''. I was just curious how one could do this. – AGS Oct 12 '12 at 14:44