Is is possible to associate part of a drawing to a pdfcomment (or similar) interactive bubble?

Question

It is apparently possible to put a TikZ drawing inside a pdfcomment (but using mbox).

Is is possible to associate only part of a drawing (e.g. a line) to a pdfcomment? Below it is the suggested code.

I am open to use other interactive packages (similar to pdfcomment) if that can solve the problem. The final goal is to associate individual curves in a pgfplot to a tooltip when dragging the mouse.

\documentclass[]{article}
\usepackage{tikz}
\usepackage[]{pdfcomment}
\begin{document}

%ok
\pdfmarkupcomment[]{
    text
}{
    a paragraph
}

% ok but needs mbox
\pdfmarkupcomment[]{
    \mbox{
    \begin{tikzpicture}
    \draw(0,0)--(1,1);
    \draw(0,1)--(1,0);
    \end{tikzpicture}}
}{
    a drawing
}

%not ok (Error: Missing } inserted.)
\begin{tikzpicture}
    \pdfmarkupcomment[]{
        \draw(0,0)--(1,1);
    }{
        a line
    }
    \draw(0,1)--(1,0);
\end{tikzpicture}

\end{document}