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You can locally redefine \printatom in order to force atom depths to 0pt: \documentclass{article} \usepackage{chemfig} \setatomsep{1.5em} \begin{document} something \( \renewcommand\printatom[1]{\setbox0=\hbox{\ensuremath{\mathrm{#1}}}\dp0=0pt \box0 } \chemfig{CH_3-*6(-=-(-CH_2-*6(-=-(-CH_2-*6(-=-(-CH_3)=-=))=-=))=-=)} \) something \end{document}



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