Here is a slight variation on Jake's solution, concerning the lines. Instead of drawing the separators separately (!), you can have them drawn up directly, by drawing the shape of the nodes. The only problem is that they will not mesh perfectly without some tweaking, but this can be done by setting the column sep with \pgflinewidth
.
The code for this is:
\documentclass{article}
\usepackage{tikz}
\usetikzlibrary{matrix}
\begin{document}
\begin{tikzpicture}
\matrix[matrix of nodes,column sep=-\pgflinewidth, name=matrix,every node/.style={draw},
minimum height=0.75cm,minimum width=2cm,text depth=0.5ex]{
1&2&3\\
};
\end{tikzpicture}
\end{document}