It depends on the context.
If this is part of a piece of text, then you might consider Peter Grill's suggestion:
$\exists a\in\mathbb{R}$, $\exists b\in\mathbb{R}$,
$\forall c\in\mathbb{R}$, and $\forall b\in\mathbb{R}$

On the other hand, if the quantifiers are part of a logical formula, you might consider a dot between the quantifiers, like this:
$\exists a\in\mathbb{R}\ldotp\exists b\in\mathbb{R}\ldotp
\forall c\in\mathbb{R}\ldotp\forall b\in\mathbb{R}\ldotp P$

This dot notation is inherited, I think, from Russell and Whitehead's Principia Mathematica, and is quite widely used, particularly in computer science. A comma between quantifiers is quite unusual, though it does appear in the syntax of the Coq theorem prover.
$\exists a\in\mathbb{R}, \exists b\in\mathbb{R},
\forall c\in\mathbb{R}, \forall d\in\mathbb{R}, P$

The comma notation becomes awkward when you want to quantify several variables at the same time, because then you have two different types of comma in the same formula:
$\exists a,b\in\mathbb{R}, \forall c,d\in\mathbb{R}, P$

In such cases, you might consider putting just a space between the variables, like this:
$\exists a\;b\in\mathbb{R}, \forall c\;d\in\mathbb{R}, P$

The idea of putting spaces between variables, rather than commas, is taken from the syntax of the Isabelle theorem prover.
$\exists a\in\mathbb{R}$, $\exists b\in\mathbb{R}$, $\forall c\in\mathbb{R}$, and $\forall b\in\mathbb{R}$
, or perhaps$\exists a, b \in\mathbb{R}$, $\forall c, d \in\mathbb{R}$
.$\exists a\in\mathbb{R}\ \exists b\in\mathbb{R}$
can help. I agree with @percusse though.