My first instinct was 'no', and I'm still leaning in that direction. JS / CSS files benefit from minification because it speeds up their downloads. The speedup in parsing may be negligible.
Also, a LaTeX minifier could perform some nifty tricks, especially if it was allowed to assume that csnames containing a
@ or starting with
__ are never referred to outside of the file.
So I think it's a question worth asking. Has anyone ever tried anything like this?