Can you use pgfplotstable to perform operations on columns?
For example, I have
\documentclass{article}
\usepackage{pgfplotstable}
\pgfplotstableread{
x y
4 2.50000000e-01
16 6.25000000e-02
64 1.56250000e-02
256 3.90625000e-03
1024 9.76562500e-04
4096 2.44140625e-04
16384 6.10351562e-05
65536 1.52587891e-05
262144 3.81469727e-06
1048576 9.53674316e-07
}\mytable
\begin{document}
\begin{minipage}[t]{0.4\linewidth}
\pgfplotstabletypeset{\mytable}
\end{minipage}
\end{document}
Can I create a 3rd column z=x-y^2