Probably it's not what you want but if there is no better solution ...
\documentclass[tikz]{standalone}
\usetikzlibrary{positioning,shapes.multipart}
\begin{document}
\begin{tikzpicture}[mynode/.style={rectangle split, rectangle split parts=2, draw, node contents=#1},
mynode/.default={A\nodepart{two}B}]
\node (A) [mynode];
\node[right=5mm of A] (B) [mynode={C}];
\node[right=5mm of B] (C) [mynode={\nodepart{two}D}];
\end{tikzpicture}
\end{document}

If you want always the same part with fixed contents, define it inside .style
and left the other one as parameter:
\documentclass[tikz]{standalone}
\usetikzlibrary{positioning,shapes.multipart}
\begin{document}
\begin{tikzpicture}[mynode/.style={rectangle split, rectangle split parts=2, draw, node contents={#1\nodepart{two}Constant}},
]
\node (A) [mynode=A];
\node[right=5mm of A] (B) [mynode=B];
\node[right=5mm of B] (C) [mynode=C];
\end{tikzpicture}
\end{document}

circle split
was an example.