If I understand your question correct, you want to set the indentation of the rows after the first one of description
-environments to 0cm. You might have a look at the enumitem
-package. With it you can adjust and finetune the description lists. But I'd recommend the enumerate
-environment:
\documentclass[]{scrartcl}
\usepackage{enumitem}
\begin{document}
Using \texttt{description}:
\begin{description}[leftmargin=0cm]
\item[Item 1] Some words.
\item[Item 2] Other words
\item[Item 3] Different words\\More words belonging to item 3
\end{description}
Using \texttt{enumerate}:
\begin{enumerate}[leftmargin=*,label=\textbf{\sffamily Item \arabic*}]
\item Some words.
\item Other words
\item Different words\\More words belonging to item 3
\end{enumerate}
\end{document}
The above code's output:

EDIT: To get the labels in the description right aligned one might use:
\documentclass[]{scrartcl}
\usepackage{enumitem}
\begin{document}
Using \texttt{description}:
\begin{description}[align=right,leftmargin=*,labelindent=5cm]
\item[Item 1] Some words.
\item[Item 2] Other words
\item[Item 3] Different words\\More words belonging to item 3
\item[Item 10000] a new item
\item[Item 100000000000] a new item
\end{description}
\end{document}
Change the labelindent=
to your liking. This results in:

Note that a too small labelindent
leads to the labels going into the margins and perhaps out of the page.
EDIT2: Perhaps a nicer approach, making the columnwidth for the labels definable (with linebreaks when possible). You can change the labelwidth=
to your liking.
\documentclass[]{scrartcl}
\usepackage{enumitem}
\SetLabelAlign{parright}{\strut\smash{\parbox[t]{\labelwidth}{\raggedleft#1}}}
\begin{document}
Using \texttt{description}:
\begin{description}[align=right,leftmargin=*,labelindent=5cm]
\item[Item 1] Some words.
\item[Item 2] Other words
\item[Item 3] Different words\\More words belonging to item 3
\item[Item 10000] a new item
\item[Item 100000000000] a new item
\end{description}
New approach using \texttt{parright}:
\begin{description}[align=parright,leftmargin=!,labelwidth=2.5cm]
\item[Item 1] Some words.
\item[Item 2] Other words
\item[Item 3] Different words\\More words belonging to item 3
\item[Item 10000] a new item
\item[Item 100000000000] a new item\\a new row
\end{description}
\end{document}
