% Leading problem between Row 2, Row3 and Row4 in case of super and subscript value
\documentclass{article}
\usepackage{cals}
\begin{document}
\par\begin{calstable}
\colwidths{{50pt}{50pt}{50pt}{50pt}}
\thead{\bfseries\brow \cell{col1} \cell{col2} \cell{col3} \cell{col4}\erow\mdseries}
\brow \cell{col1}\cell{r1,col2} \cell{r1,col3} \cell{col4}\erow
\brow \cell{col1} \cell{r2,col2} \cell{r2,col3} \cell{col4}\erow
\brow \cell{col1$_3^3$} \cell{r3,col2$^1_5$} \cell{r3,col3}\cell{col4} \erow
\brow \cell{col1} \cell{r4,col2} \cell{r4,col3} \cell{col4}\erow
\brow \cell{col1$5^+_5$} \cell{r5,col2} \cell{r5,col3} \cell{col4}\erow
\end{calstable}
\end{document}