A good. modern replacement for mathpple
/mathpazo
/pxfonts
/newpxmath
is Asana Math, which was originally based on Young Ryu’s pxfonts
.
\documentclass[a4paper,10pt,reqno,oldfontcommands]{memoir}
\usepackage[centertags]{amsmath}
\usepackage{unicode-math}
\defaultfontfeatures{Scale=MatchLowercase}
\setmainfont{TeX Gyre Pagella}[Scale = 1.0, Ligatures={Common, TeX}]
\setmathfont{Asana Math}
% If you’re using mathrsfs, you probably want to use \mathscr, but you also
% load amssymb. The following line sets up a \mathcal and \mathbfcal similar
% to the ones from ammsymb, in addition to \mathscr and \mathbfscr similar to
% rsfs.
\setmathfont[range={cal,bfcal}, Alternate]{Asana Math}
% URW Classico is a free clone of Optima, which matches the free clones of
% Palatino well.
%\setsansfont{URWClassico}[
% UprightFont = *-Regular ,
% BoldFont = *-Bold ,
% ItalicFont = *-Italic ,
% BoldItalicFont = *-BoldItalic ,
% Extension = .ttf ]
%\setmonofont{Inconsolata} % A humanist monospaced font.
\newcommand*\dif{\mathop{}\mathrm{d}}
\begin{document}
\section{A Section}
This should be a triple integral:
\begin{align}
\iiint\limits_V \dif V \, (\nabla\phi)^2 = 0.
\label{eqn:triple_integral}
\end{align}
\end{document}

For comparison, mathpazo
with a double integral:
\documentclass[a4paper,10pt,reqno,oldfontcommands]{memoir}
\usepackage[T1]{fontenc}
\usepackage{textcomp}
\usepackage[utf8]{inputenc} % The default since 2018.
\usepackage[centertags]{amsmath}
\usepackage{amssymb}
\usepackage{mathrsfs}
\usepackage{mathpazo}
\newcommand*\dif{\mathop{}\mathrm{d}}
\begin{document}
\section{A Section}
This should be a triple integral:
\begin{align}
\iint\limits_V \dif V \, (\nabla\phi)^2 = 0.
\label{eqn:triple_integral}
\end{align}
\end{document}

My recommendation is to use unicode-math
whenever you can, and legacy font packages when you have to. Any modern math font has more symbols with more consistency and more flexibility than any combination of legacy packages. If you’re stuck with PDFTeX, I suggest replacing \usepackage{mathpazo}
with \usepackage{newpxtext, newpxmath}
.