You can create a new command that does the trick with everything you know about counters ;)
\documentclass{article}
\newcommand{\myitem}{\addtocounter{enumi}{3}\item}
\begin{document}
\begin{enumerate}
\myitem One
\myitem Two
\myitem \dots
\end{enumerate}
\end{document}

You could create a new command with a step size as argument as well:
\newcommand{\myitem}[1]{\addtocounter{enumi}{\numexpr#1-1\relax}\item}
Or "set a step size" in the beginning:
\documentclass{article}
\let\olditem\item
\newcommand{\myitem}[1]{\addtocounter{enumi}{\numexpr#1-1\relax}\olditem}
\newcommand{\setenumstep}[1]{%
\renewcommand{\item}{\myitem#1}
}
\begin{document}
\begin{enumerate}
\myitem4 One
\myitem4 Two
\myitem4 \dots
\end{enumerate}
\begin{enumerate}
\setenumstep{4}
\item One
\item Two
\item \dots
\end{enumerate}
\end{document}
These enumerations both result in the same as the first one posted.
Probably you know it already, but might be helpful anyway: If you want to tweak single items, you can do it manually with
\item[4.] One
\item[8.] Two