OK, per request. Note that this is a very simple example, and you will be even better off if you just use <1-2>
and the like for the items. However, for more complex examples this may pay off. In any case, I will be happy to remove this if it is not useful.
\documentclass{beamer}
\usepackage{tikzducks,tikzlings}
\newcommand{\topA}{\begin{itemize}
\item this is a duck: \tikz[baseline=2em]{\duck}
\end{itemize}}
\newcommand{\botA}{\begin{itemize}
\item this is a mouse: \tikz[baseline=2em]{\mouse}
\end{itemize}}
\newcommand{\topB}{\begin{itemize}
\item this is a koala: \tikz[baseline=2em]{\koala}
\end{itemize}}
\newcommand{\botB}{\begin{itemize}
\item this is a marmot: \tikz[baseline=2em]{\marmot}
\end{itemize}}
\begin{document}
\begin{frame}[t]
\frametitle{Ti\emph{k}Zlings: duck and mouse}
\topA
\botA
\end{frame}
\begin{frame}[t]
\frametitle{Ti\emph{k}Zlings: mouse and koala}
\botA
\topB
\end{frame}
\begin{frame}[t]
\frametitle{Ti\emph{k}Zlings: koala and marmot}
\topB
\botB
\end{frame}
\end{document}

This, which is conceptually very similar tp leandriis' suggestion yields almost the same result (except for no top alignment, which I fail to understand, but this is definitely my fault).
\documentclass{beamer}
\usepackage{tikzducks,tikzlings}
\begin{document}
\begin{frame}[t]
\frametitle{Ti\emph{k}Zlings: \only<1>{duck}\only<2>{mouse}\only<3>{koala} and
\only<1>{mouse}\only<2>{koala}\only<3>{marmot}}
\begin{itemize}
\item<1> this is a duck: \tikz[baseline=2em]{\duck}
\item<1-2> this is a mouse: \tikz[baseline=2em]{\mouse}
\item<2-3> this is a koala: \tikz[baseline=2em]{\koala}
\item<3> this is a marmot: \tikz[baseline=2em]{\marmot}
\end{itemize}
\end{frame}
\end{document}
So I guess we will have to wait until @samcarter writes a real answer.
\topN
,\botN
,\topM
,\botM
and could then use\begin{frame}\frametitle{...} \topN \botN \end{frame} \begin{frame}\frametitle{...} \botN \topM \end{frame} \begin{frame}\frametitle{...} \topM \botM \end{frame}
etc.\documentclass{beamer} \begin{document} \begin{frame} \begin{itemize} \item<1-> visible on first slide \item<3-> visible on third slide \end{itemize} \begin{enumerate} \item<1-> visible on first slide \item<2-> visible on second slide \end{enumerate} \end{frame} \end{document}