Depending on the definition of 'reasonable', it can be done.
One option is to set a custom footline with color and additional text commands in it and set the definitions for these commands in \only<.>
commands. At the start of a new frame you can set them back to the original values. The question did not say which theme is used so I took a standard example - you may need to adjust the footline
template to match your presentation.
MWE:
\documentclass[10pt,xcolor=dvipsnames]{beamer}
\usepackage{etoolbox}
\setbeamertemplate{navigation symbols}{}
\setbeamertemplate{footline}
{
\leavevmode%
\hbox{%
\begin{beamercolorbox}[wd=.4\paperwidth,ht=2.25ex,dp=1ex,center]{author in head/foot}%
\usebeamerfont{author in head/foot}\insertshortauthor
\end{beamercolorbox}%
\begin{beamercolorbox}[wd=.6\paperwidth,ht=2.25ex,dp=1ex,center]{title in head/foot}%
\usebeamerfont{title in head/foot}\insertshorttitle\hspace*{3em}%
% modification of the footline using \mycolor and \mysymbol here
\hfill \color{\mycolor}\mysymbol\insertframenumber{} / \inserttotalframenumber\hspace*{1ex}
\end{beamercolorbox}}%
\vskip0pt%
}
\setbeamerfont{footline}{size=\normalsize}
\author{John Doe}
\title{My presentation}
\def\mycolor{blue}
\def\mysymbol{\relax}
\BeforeBeginEnvironment{frame}{\gdef\mycolor{blue}\gdef\mysymbol{\relax}}
\def\setlast{\only<.>{\gdef\mycolor{red}\gdef\mysymbol{*}}}
\begin{document}
\begin{frame}
\begin{itemize}
\item<+-> one
\item<+-> two
\item<+-> three
\end{itemize}
\setlast
\end{frame}
\setbeamercolor{page number in head/foot}{fg=red}
\begin{frame}
\begin{itemize}
\item<+-> one one
\item<+-> two two
\item<+-> three three
\end{itemize}
\setlast
\end{frame}
\end{document}
\end{document}
Result:

Note that you have to insert \setlast
manually at the end of each frame. I tried to automate this but I'm not really sure where to hook into - this can probably be improved.