You may want to try the following redefinitions.
\documentclass[american]{article}
\usepackage[T1]{fontenc}
\usepackage[utf8]{inputenc}
\usepackage{babel}
\usepackage{csquotes}
\usepackage[backend=biber,
style=nature,
intitle=true,
isbn=false, doi=false, url=false, eprint=false,
]{biblatex}
\DeclareFieldFormat[article]{citetitle}{#1}
\DeclareFieldFormat{booktitle}{\textbf{#1}\isdot}
\DeclareFieldFormat{journaltitle}{\textbf{#1}\isdot}
\DeclareFieldFormat*{volume}{#1}
\renewbibmacro*{journal+issuetitle}{%
\usebibmacro{journal}%
\setunit*{\addspace}%
\iffieldundef{series}
{}
{%
\newunit
\printfield{series}%
\setunit{\addspace}%
}%
\setunit{\addspace}%
\printfield{issue}%
\setunit*{\addspace}%
\usebibmacro{date}%
\setunit{\addsemicolon\space}%
\printfield{volume}%
\newunit
\usebibmacro{issue}%
\newunit
}
\renewbibmacro{issue+date}{}
\addbibresource{biblatex-examples.bib}
\begin{document}
\autocite{sigfridsson,aksin}
\printbibliography
\end{document}

If you want to know which bibmacros or field definitions you need to change, you usually have to have a look at the source of the bibliography style you are using. For @article
, the type discussed in the question, nature.bbx
has
\DeclareBibliographyDriver{article}{%
\usebibmacro{bibindex}%
\usebibmacro{begentry}%
\usebibmacro{author/translator+others}%
\setunit{\labelnamepunct}\newblock
\iftoggle{bbx:articletitle}
{%
\usebibmacro{title}%
\newblock
}
{}%
\printlist{language}%
\newunit\newblock
\usebibmacro{byauthor}%
\newunit\newblock
\usebibmacro{bytranslator+others}%
\newunit\newblock
\printfield{version}%
\newunit\newblock
\usebibmacro{journal+issuetitle}%
\newunit
\usebibmacro{byeditor+others}%
\newunit
\usebibmacro{note+pages}%
\newunit
\iftoggle{bbx:isbn}
{\printfield{issn}}
{}%
\newunit\newblock
\usebibmacro{doi+eprint+url}%
\setunit{\addspace}\newblock
\usebibmacro{issue+date}%
\newunit\newblock
\usebibmacro{addendum+pubstate}%
\setunit{\bibpagerefpunct}\newblock
\usebibmacro{pageref}%
\newunit\newblock
\iftoggle{bbx:related}
{\usebibmacro{related:init}%
\usebibmacro{related}}
{}%
\usebibmacro{finentry}%
}
Some guessing and a bit of trial and error shows that the bibmacro journal+issuetitle
prints the journal title and volume, number information. note+pages
prints the pages and issue+date
the date.
So step one is to redefine issue+date
to do nothing. The second step is to insert code to print the date after the journal title. To do that we redefine journal+issuetitle
, which is originally defined in nature.bbx
as
\renewbibmacro*{journal+issuetitle}{%
\usebibmacro{journal}%
\setunit*{\addspace}%
\iffieldundef{series}
{}
{%
\newunit
\printfield{series}%
\setunit{\addspace}%
}%
\printfield{volume}%
\newunit
\usebibmacro{issue}%
\newunit
}
You'll notice that the code we added to journal+issuetitle
is a simplified version of nature.bbx
's issue+date
\renewbibmacro*{issue+date}{%
\iffieldundef{year}
{}
{%
\iffieldundef{issue}
{\printtext[parens]{\usebibmacro{date}}}
{%
\printtext[parens]{%
\printfield{issue}%
\setunit*{\addspace}%
\usebibmacro{date}%
}%
}%
}%
\newunit
}
The bottom line is: If you want to know which macros you need to redefine, check the implementation in the .bbx
and .cbx
files and chase down the bibmacro definitions.