I have a problem with a vertical gap appearing in the second column of the second page, instead of text/figure. This problem is not exclusive to the pages near the bibliography because this gap also appeared in another page. Please advise on how I can pull up the text/figure to the top of second column (I'm using the oxford bioinformatics template https://www.overleaf.com/latex/templates/template-for-oxford-bioinformatics-journal-new-version/zjrmbrmtrytg).
\PassOptionsToPackage{utf8}{inputenc}
\documentclass{bioinfo}
\copyrightyear{2015} \pubyear{2015}
\usepackage{comment}
\usepackage[caption=false]{subfig}
\usepackage{lipsum}
\access{Advance Access Publication Date: Day Month Year}
\appnotes{Manuscript Category}
\begin{document}
%\firstpage{1}
\lipsum[90-100]
\begin{figure}[!tpb]%figure1
\fboxsep=0pt\colorbox{gray}{\begin{minipage}[t]{235pt} \vbox to 100pt{\vfill\hbox to
235pt{\hfill\fontsize{24pt}{24pt}\selectfont FPO\hfill}\vfill}
\end{minipage}}
%\centerline{\includegraphics{fig01.eps}}
\caption{Caption, caption.}\label{fig:01}
\end{figure}
\begin{figure}[!tpb]%figure1
\fboxsep=0pt\colorbox{gray}{\begin{minipage}[t]{235pt} \vbox to 100pt{\vfill\hbox to
235pt{\hfill\fontsize{24pt}{24pt}\selectfont FPO\hfill}\vfill}
\end{minipage}}
\caption{Caption, caption.}\label{fig:01}
\end{figure}
\begin{figure}[!tpb]%figure1
\fboxsep=0pt\colorbox{gray}{\begin{minipage}[t]{235pt} \vbox to 100pt{\vfill\hbox to
235pt{\hfill\fontsize{24pt}{24pt}\selectfont FPO\hfill}\vfill}
\end{minipage}}
\caption{Caption, caption.}\label{fig:02}
\end{figure}
\begin{figure}[!tpb]%figure1
\fboxsep=0pt\colorbox{gray}{\begin{minipage}[t]{235pt} \vbox to 100pt{\vfill\hbox to
235pt{\hfill\fontsize{24pt}{24pt}\selectfont FPO\hfill}\vfill}
\end{minipage}}
\caption{Caption, caption.}\label{fig:03}
\end{figure}
\section*{Acknowledgements}
Text Text Text Text Text Text Text Text. \citealp{Boffelli03} might want to know about text
text text text\vspace*{-12pt}
\section*{Funding}
This work has been supported by the... Text Text Text Text.\vspace*{-12pt}
\bibliographystyle{natbib}
%\bibliography{document}
\begin{thebibliography}{}
\bibitem[Bofelli {\it et~al}., 2000]{Boffelli03}
Bofelli,F., Name2, Name3 (2003) Article title, {\it Journal Name}, {\bf 199}, 133-154.
\bibitem[Bag {\it et~al}., 2001]{Bag01}
Bag,M., Name2, Name3 (2001) Article title, {\it Journal Name}, {\bf 99}, 33-54.
\bibitem[Yoo \textit{et~al}., 2003]{Yoo03}
Yoo,M.S. \textit{et~al}. (2003) Oxidative stress regulated genes in nigral dopaminergic neurnol cell: correlation with the known pathology in Parkinson's disease. \textit{Brain Res. Mol. Brain Res.}, \textbf{110}(Suppl. 1), 76--84.
\bibitem[Lehmann, 1986]{Leh86}
Lehmann,E.L. (1986) Chapter title. \textit{Book Title}. Vol.~1, 2nd edn. Springer-Verlag, New York.
\bibitem[Crenshaw and Jones, 2003]{Cre03}
Crenshaw, B.,III, and Jones, W.B.,Jr (2003) The future of clinical cancer management: one tumor, one chip. \textit{Bioinformatics}, doi:10.1093/bioinformatics/btn000.
\bibitem[Auhtor \textit{et~al}. (2000)]{Aut00}
Auhtor,A.B. \textit{et~al}. (2000) Chapter title. In Smith, A.C. (ed.), \textit{Book Title}, 2nd edn. Publisher, Location, Vol. 1, pp.???--???.
\bibitem[Bardet, 1920]{Bar20}
Bardet, G. (1920) Sur un syndrome d'obesite infantile avec polydactylie et retinite pigmentaire (contribution a l'etude des formes cliniques de l'obesite hypophysaire). PhD Thesis, name of institution, Paris, France.
\bibitem[Bofelli {\it et~al}., 2000]{Boffelli03}
Bofelli,F., Name2, Name3 (2003) Article title, {\it Journal Name}, {\bf 199}, 133-154.
\bibitem[Bag {\it et~al}., 2001]{Bag01}
Bag,M., Name2, Name3 (2001) Article title, {\it Journal Name}, {\bf 99}, 33-54.
\bibitem[Yoo \textit{et~al}., 2003]{Yoo03}
Yoo,M.S. \textit{et~al}. (2003) Oxidative stress regulated genes in nigral dopaminergic neurnol cell: correlation with the known pathology in Parkinson's disease. \textit{Brain Res. Mol. Brain Res.}, \textbf{110}(Suppl. 1), 76--84.
\bibitem[Lehmann, 1986]{Leh86}
Lehmann,E.L. (1986) Chapter title. \textit{Book Title}. Vol.~1, 2nd edn. Springer-Verlag, New York.
\bibitem[Crenshaw and Jones, 2003]{Cre03}
Crenshaw, B.,III, and Jones, W.B.,Jr (2003) The future of clinical cancer management: one tumor, one chip. \textit{Bioinformatics}, doi:10.1093/bioinformatics/btn000.
\bibitem[Auhtor \textit{et~al}. (2000)]{Aut00}
Auhtor,A.B. \textit{et~al}. (2000) Chapter title. In Smith, A.C. (ed.), \textit{Book Title}, 2nd edn. Publisher, Location, Vol. 1, pp.???--???.
\bibitem[Bardet, 1920]{Bar20}
Bardet, G. (1920) Sur un syndrome d'obesite infantile avec polydactylie et retinite pigmentaire (contribution a l'etude des formes cliniques de l'obesite hypophysaire). PhD Thesis, name of institution, Paris, France.
\bibitem[Bofelli {\it et~al}., 2000]{Boffelli03}
Bofelli,F., Name2, Name3 (2003) Article title, {\it Journal Name}, {\bf 199}, 133-154.
\bibitem[Bag {\it et~al}., 2001]{Bag01}
Bag,M., Name2, Name3 (2001) Article title, {\it Journal Name}, {\bf 99}, 33-54.
\bibitem[Yoo \textit{et~al}., 2003]{Yoo03}
Yoo,M.S. \textit{et~al}. (2003) Oxidative stress regulated genes in nigral dopaminergic neurnol cell: correlation with the known pathology in Parkinson's disease. \textit{Brain Res. Mol. Brain Res.}, \textbf{110}(Suppl. 1), 76--84.
\bibitem[Lehmann, 1986]{Leh86}
Lehmann,E.L. (1986) Chapter title. \textit{Book Title}. Vol.~1, 2nd edn. Springer-Verlag, New York.
\bibitem[Crenshaw and Jones, 2003]{Cre03}
Crenshaw, B.,III, and Jones, W.B.,Jr (2003) The future of clinical cancer management: one tumor, one chip. \textit{Bioinformatics}, doi:10.1093/bioinformatics/btn000.
\bibitem[Auhtor \textit{et~al}. (2000)]{Aut00}
Auhtor,A.B. \textit{et~al}. (2000) Chapter title. In Smith, A.C. (ed.), \textit{Book Title}, 2nd edn. Publisher, Location, Vol. 1, pp.???--???.
\bibitem[Bardet, 1920]{Bar20}
Bardet, G. (1920) Sur un syndrome d'obesite infantile avec polydactylie et retinite pigmentaire (contribution a l'etude des formes cliniques de l'obesite hypophysaire). PhD Thesis, name of institution, Paris, France.
\bibitem[Bofelli {\it et~al}., 2000]{Boffelli03}
Bofelli,F., Name2, Name3 (2003) Article title, {\it Journal Name}, {\bf 199}, 133-154.
\bibitem[Bag {\it et~al}., 2001]{Bag01}
Bag,M., Name2, Name3 (2001) Article title, {\it Journal Name}, {\bf 99}, 33-54.
\bibitem[Yoo \textit{et~al}., 2003]{Yoo03}
Yoo,M.S. \textit{et~al}. (2003) Oxidative stress regulated genes in nigral dopaminergic neurnol cell: correlation with the known pathology in Parkinson's disease. \textit{Brain Res. Mol. Brain Res.}, \textbf{110}(Suppl. 1), 76--84.
\bibitem[Lehmann, 1986]{Leh86}
Lehmann,E.L. (1986) Chapter title. \textit{Book Title}. Vol.~1, 2nd edn. Springer-Verlag, New York.
\bibitem[Crenshaw and Jones, 2003]{Cre03}
Crenshaw, B.,III, and Jones, W.B.,Jr (2003) The future of clinical cancer management: one tumor, one chip. \textit{Bioinformatics}, doi:10.1093/bioinformatics/btn000.
\bibitem[Auhtor \textit{et~al}. (2000)]{Aut00}
Auhtor,A.B. \textit{et~al}. (2000) Chapter title. In Smith, A.C. (ed.), \textit{Book Title}, 2nd edn. Publisher, Location, Vol. 1, pp.???--???.
\bibitem[Bardet, 1920]{Bar20}
Bardet, G. (1920) Sur un syndrome d'obesite infantile avec polydactylie et retinite pigmentaire (contribution a l'etude des formes cliniques de l'obesite hypophysaire). PhD Thesis, name of institution, Paris, France.
\end{thebibliography}
\end{document}
lipsumpackage for blind text, which will help you make your MWE a bit more minimal. This helps to highlight the actual issue without having to repeat the wordtextso often.sf4e_5.texthat is causing this.picture(0,0)(35,0)...text in the four corners where there should be crop marks. So there is something fishy in your document.\raggedendafter\begin{document}. I can't reconstruct your problem, so I can't check if this works.