I've found that MikTeX now have both x86 and x86_64 version.
What's the difference between them? Are there are some limitations in the x86_64? Or they are completely interchangeably?
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There are no significant performance differences between the x86/64 versions of MiKTeX. But between MiKTeX and TeX Live, particularly with including, scaling and other operations on pdf pages.
And there is no biber in MiKTeX 64.1